Impact of vitamin D deficiency on the clinical presentation and prognosis of patients with newly diagnosed multiple myeloma
We studied 148 newly diagnosed MM patients from January 1, 2004 through December 31, 2008 who had a serum 25-hydroxyvitamin D [25(OH)D] obtained within 14 days of diagnosis. Subjects with vitamin D deficiency [25(OH)D level less than 50 nmol/L (20 ng/mL)] had higher mean values of serum C-reactive protein (CRP) (2.40 mg/L vs. 0.84 mg/L, p= 0.02) and creatinine (1.75 mg/dL vs. 1.24 mg/dL, p=0.03) and lower serum albumin values (3.12 g/dL vs. 3.39 g/dL, p=0.003) compared to subjects without vitamin D deficiency.
n this study population of newly diagnosed MM patients, 24% of subjects had vitamin D deficiency, as defined by having a serum 25(OH)D level of less than 50 nmol/L (20 ng/mL).
we found higher serum CRP and creatinine levels in subjects with vitamin D deficiency. vitamin D deficiency may be predictive of a poorer outcome in MM.
Prevalence of Vitamin D Deficiency in Patients with Bone Metastases and Multiple Myeloma
several studies demonstrated that endocrine changes such as vitamin D deficiency promote secondary cancer growth in bone, relatively few have reported its prevalence. For this reason, the purpose of the present study was to evaluate the prevalence of hypovitaminosis D in patients with bone metastases and multiple myeloma.
vitamin D is a major regulator of calcium homeostasis
vitamin D deficiency significantly stimulated skeletal tumor growth in a number of different cancer models
Low dietary calcium promotes breast cancer growth in bone
A recently-published study on a high vitamin-D bread tells us that as many as 70% of the U.S. population may have insufficient vitamin D status.
CONCLUSIONS: 4 weeks of 3x per week in tanning bed is more effective than taking Vit D pills!
The present study shows that 12 NB-UVB exposures given during 4 weeks increase serum 25(OH)D concentration significantly more than 20 μg of oral cholecalciferol daily.
CONCLUSIONS – just minimal tanning is enough to produce Vit D:
The response of 25-OH-D levels to UVB light is dependent on skin pigmentation and the amount of UVB given, and useful increases in vitamin D status can be achieved by defined UVB doses small enough to produce only minimal tanning
CONCLUSIONS- one dose of 300K IU vit D3 raised serum concentrations to right level – that helps calcium absorption and less fractures!
a single oral dose of 300000 IU vitamin D3 raises mean 25(OH)D serum concentrations to the target mean of above 75 nmol/l at 3 months and a mean level of 69 nmol/l at 6 months. As calcium absorption is enhanced with higher 25(OH)D serum concentrations, calcium supplementation may need downward adjustment
We identified 290 prospective cohort studies (279 on disease occurrence or mortality, and 11 on cancer characteristics or survival), and 172 randomized trials of major health outcomes and of physiolo