Sea Cucumber

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3/15/16 I started to take SeaCare – TBL-12 is a complex product with four different sea products.  It is high quality, gelatinous, and shipped in from Australia. TBL-12 was first discovered by Sam Grant Sr, who in 1962 was given 6 months to live with Stomach Cancer. Sam took his family to the far end of Queensland and whille there he met and helped a Chinese fisherman who saw his deteriorating condition and showed him how to prepare the marine ingredients that still are used to make TBL-12.  This formula made it through clinical trials and achieved “orphan drug” status before the developers ran out of money to continue the trial.

http://naturalsociety.com/sea-cucumber-shrinks-cancer-cells-95-percent/

Sea Cucumber Found to Kill 95% of Cancer Cells, Shrink Tumors

Sea cucumber has been used in traditional Chinese medicine for hundreds of years, but they are relatively obscure in the U.S. This may be soon changing, however, as evidence mounts that sea cucumber extracts can kill cancer cells while stimulating the immune system.

Websites that have research data

Table of Contents (links below this list)

  1. Sloan Kettering
  2. PubMed 11421733 – Sea Cucumber & Herpes Simplex
  3. ”                   12932123  3 substances in Sea Cucumber are toxic against 10 human tumor cell lines
  4.         ”           15844944  6 substances in Sea Cucumber toxic to 10 human tumor cell lines
  5.  article on healing mouth tissue
  6.         ”           18841904 – structure of Sea cucumber
  7.         ”            21756184         “
  8.  anticoagulation properties of sea cucumber
  9.        ”            23308143  – Sea Cucumber with lung, pancreatic, leukemia & breast cancer
  10.       ”             26861868    3 substances that inhibited cancer cell prolif
  11.       ”            26194305    Sea Cuc lowers glucose in insulin resistant mice
  12.       ”           25984989    Anticancer agents in Sea Cucumbers
  13.       ”          PMC4446612 Sea Cucumber on Prostate cancer
  14.       ”          15645493   Sea Cucumber may inhibit RTK’s
  15.                    PMC3210605
  16. Blogs  about using Sea Cucumber

 

  1. From Sloan Kettering:

https://www.mskcc.org/cancer-care/integrative-medicine/herbs/sea-cucumber

Scientific name: Staurocucumis liouvillei, Mensamaria intercedens Lampert, Cucumaria frondosa

Do not take if:

  • You are allergic to seafood.
  • You are taking anticoagulants: The polysaccharides present in sea cucumber may increase the effects of anticoagulants, increasing the risk of bleeding.

In vitro studies have shown that the saponins and fatty acids present in sea cucumber are responsible for its anti-angiogenic, anti-tumor (2), antiproliferative (1), and antiviral properties (4) (3).

A branched-chain fatty acid known as 12-methyltetradecanoic acid, isolated from sea cucumber, is thought to inhibit prostate cancer cell proliferation by increasing caspase-3 activity (1). The proposed mechanism for the anti-angiogenic and antitumor effects of Philinopside A, a saponin derived from sea cucumber, is by inhibiting tyrosine kinase receptors (2). Frondoside A, a triterpenoid glycoside from Cucumaria frondosa, also has anti-angiogenic activity.

2. Maier MS, et al. Two new cytotoxic and virucidal trisulfated triterpene glycosides from the Antarctic sea cucumber Staurocucumis liouvillei.   http://www.ncbi.nlm.nih.gov/pubmed/11421733

J Nat Prod 2001; 64(6):732-36. Two new trisulfated triterpene glycosides, liouvillosides A (1) and B (2), have been isolated from the Antarctic sea cucumber Staurocucumis liouvillei… Both glycosides were found to be virucidal against herpes simplex virus type 1 (HSV-1) at concentrations below 10 microg/mL.

3.   Zou ZR, et al. Intercedensides A-C, three new cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert. J Nat Prod 2003; 66(8):105560. http://www.ncbi.nlm.nih.gov/pubmed/12932123

All three glycosides showed significant cytotoxicity against 10 human tumor cell lines

4.   Zou Z1, Yi Y, Wu H, Yao X, Du L, Jiuhong W, Liaw CC, Lee KH. http://www.ncbi.nlm.nih.gov/pubmed/15844944

Intercedensides D-I, cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert. Six new triterpene glycosides, intercedensides D-I (1-6), were isolated from the whole bodies of the sea cucumber Mensamria intercedens Lampert Intercedensides D-H (1-5) showed significant cytotoxicity (ED(50) 0.96-5.0 mug/mL) against 10 human tumor cell lines.

5.   Taiyeb-Ali TB, et al. Efficacy of ’Gamadent’ toothpaste on the healing of gingival tissues: a preliminary report. J Oral Sci 2003; 45(3):153-59.

6.    Antonov AS, Avilov SA, Kalinovsky AI, et al. http://www.ncbi.nlm.nih.gov/pubmed/18841904

Triterpene glycosides from Antarctic sea cucumbers. 1. Structure of liouvillosides A1, A2, A3, B1, and B2 from the sea cucumber Staurocucumis liouvillei: New procedure for separation of highly polar glycoside fractions and taxonomic revision. J Nat Prod. 2008 Oct;71(10):1677-85.

7.   Antonov AS, Avilov SA, Kalinovsky AI, et al. http://www.ncbi.nlm.nih.gov/pubmed/21756184

Triterpene glycosides from Antarctic sea cucumbers III. Structures of liouvillosides A(4) and A(5), two minor disulphated tetraosides containing 3-O-methylquinovose as terminal monosaccharide units from the sea cucumber Staurocucumis liouvillei (Vaney). Nat Prod Res. 2011 Aug;25(14):1324-33.

8.  Fonseca RJ, Santos GR, Mourão PA. Effects of polysaccharides enriched in 2,4-disulfated fucose units on coagulation, thrombosis and bleeding. Practical and conceptual implications. Thromb Haemost. 2009 Nov;102(5):829-36.

9.   Attoub S, Arafat K, Ge´laude A, et al. Frondoside A Suppressive Effects on Lung Cancer Survival, Tumor Growth, Angiogenesis, Invasion, and Metastasis. PLoS ONE 2013; 8(1): e53087. doi:10.1371/journal.pone.0053087   http://www.ncbi.nlm.nih.gov/pubmed/23308143

Recent studies demonstrate that low concentrations of Frondoside A inhibit the growth and induced apoptosis of human pancreatic, leukemia and breast cancer cells via caspase activation

10.  http://www.ncbi.nlm.nih.gov/pubmed/26861868

2016 Mar;51(3):321-34. doi: 10.1007/s11745-016-4128-y. Epub 2016 Feb 10.

three glucocerebroside series of sea cucumber Cucumaria frondosa were isolated and evaluated in HepG2 cells all of three glucocerebroside series exhibited an inhibitory effects on cell proliferation.

11.  http://www.ncbi.nlm.nih.gov/pubmed/26194305

Fucoidan from sea cucumber Cucumaria frondosa exhibits anti-hyperglycemic effects in insulin resistant mice via activating the PI3K/PKB pathway and GLUT4.

12.  http://www.ncbi.nlm.nih.gov/pubmed/25984989 2015 May 12;13(5):2909-23. doi: 10.3390/md13052909.

Sea Cucumbers Metabolites as Potent Anti-Cancer Agents.

Janakiram NB1, Mohammed A2, Rao CV3.

Sea cucumbers and their extracts have gained immense popularity and interest among researchers and nutritionists due to their nutritive value, potential health benefits, and use in the treatment of chronic inflammatory diseases…. most sea cucumber extracts are being studied for their anti-inflammatory functions, immunostimulatory properties, and for cancer prevention and treatment

 13.  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446612/

We have extensively studied the efficacy of this extract in preventing colon cancer in rodent models. In this review, we discuss the anti-inflammatory, immunostimulatory, and anti-tumor properties of sea cucumber extracts.Yang P, et al. Inhibition of proliferation of PC3 cells by the branched-chain fatty acid, 12-methyltetradecanoic acid, is associated with inhibition of 5-lipoxygenase. Prostate 2003; 55(4):281-91. Branched-chain fatty acids or fatty alcohols have been reported to possess anti-tumor activity in various tumor models. Here we study 12-methyltetradecanoic acid (12-MTA), a branched-chain fatty acid, isolated from a sea cucumber extract, on the growth of prostate cancer cells and investigate the underlying mechanisms of its effect

14. http://www.ncbi.nlm.nih.gov/pubmed/15645493

Tong Y, et al. Philinopside A, a novel marine-derived compound possessing dual anti-angiogenic and anti-tumor effects. Int J Cancer 2005; 114(6):843-53. Philinopside A is a novel sulfated saponin isolated from the sea cucumber, Pentacta quadrangulari. results suggest that philinopside A is a promising anti-cancer agent that possesses dual cytotoxic and anti-angiogenic effects that were at least partly due to its inhibitory effects on RTKs.

15.  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210605/

High-Value Components and Bioactives from Sea Cucumbers for Functional Foods—A Review

  • Anti-Hypertension and Angiotensin Converting Enzyme (ACE) Inhibition
  •  Anti-Inflammatory
  •  Antimicrobial
  • Antioxidant
  • Anti-Thrombotic
  • Antitumor
  • Antiviral
  • Osteoarthritis
  • Wound Healing

16.   http://m.bloodjournal.org/content/124/21/5733

A Phase II Trial of TBL12 Sea Cucumber Extract in Patients with Untreated Asymptomatic Myeloma

Twenty patients were enrolled in the study. TBL12 was administered orally at a dose of 2 units (of 20 mL each) twice a day

Results:

Of the 20 patients enrolled in the study, 5 patients were taken off the TBL12 protocol due to either personal choice or noncompliance. Among the remaining 15 patients, the length of follow-up ranged from 8.5 months to 31 months, with a median follow-up period of 21 months. The trial was stopped in December 2013. Five of the patients developed progressive disease while receiving TBL12; four of these patients developed new lytic bone lesions and one patient progressed by paraprotein measurement. Including all original 20 patients in the study, the median duration of response was 19.75 months. Excluding the 5 patients who were taken off the TBL12 protocol due to either personal choice or noncompliance, the median duration of response was 21 months.

The patients reported improvement in quality of life measures

17. The following are blogs with discussion about Sea Cucumber:

  1. http://multiplemyelomablog.com/2013/03/could-myeloma-cure-lay-deep-beneath-the-sea.html
  2. 2. http://margaret.healthblogs.org/other-alternative-treatments/sea-cucumbers
  3. 3. http://www.gaynorwellness.com/sea-cucumbers-marine-bottom-dwellers-anticancer-effects/
  4. www.thecancerhasgone.com