Curcumin –

Curcumin is an iron chelator and iron stimulates my blood cancer.

Here is an amazing link: This woman lives in Italy and has had MGUS – that progressed to MM but has gone back down for 15 years! She has a good search function on the website. Look up Curcumin – she thinks Curcumin is THE key for her.
http://margaret.healthblogs.org/

1.  http://www.ncbi.nlm.nih.gov/pubmed/12680238?dopt=Abstract

Curcumin (diferuloylmethane)  Extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer

Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis. Pharmacologically, curcumin has been found to be safe. Human clinical trials indicated no dose-limiting toxicity when administered at doses up to 10 g/day. All of these studies suggest that curcumin has enormous potential in the prevention and therapy of cancer.

2.

The study investigated the effect curcumin has on 29 different human myeloma cell lines. It found that 16 of the cell lines were “highly” sensitive to myeloma, 6 were “intermediately” sensitive, and 7 were “weakly” sensitive. However, the authors write in the conclusion to their abstract that, “Altogether, these results support clinical trials including curcumin in association with standard therapy.” It is worth noting that one of the co-authors of the study is Dr. Philippe Moreau, one of the leading myeloma specialists in France. Here’s more information about the study: P Gomez-Bougie et al., “Curcumin induces cell death of the main molecular myeloma subtypes, particularly the poor prognosis subgroups,” Cancer Biology & Therapy, 2014

3.  http://www.ncbi.nlm.nih.gov/pubmed/22473809

we performed a randomised, double-blind placebo-controlled cross-over study, followed by an open-label extension study using an 8g dose to assess the effect of curcumin on FLC response and bone turnover in patients with MGUS and SMM. 36 patients (19 MGUS and 17 SMM) were randomised into two groups: one received 4g curcumin and the other 4g placebo, crossing over at 3 months. At completion of the 4g arm, all patients were given the option of entering an open-label, 8g dose extension study. Blood and urine samples were collected at specified intervals for specific marker analyses. Group values are expressed as mean ± 1 SD. Data from different time intervals within groups were compared using Student’s paired t-test. 25 patients completed the 4g cross-over study and 18 the 8g extension study. Curcumin therapy decreased the free light-chain ratio (rFLC), reduced the difference between clonal and nonclonal light-chain (dFLC) and involved free light-chain (iFLC). uDPYD, a marker of bone resorption, decreased in the curcumin arm and increased on the placebo arm. Serum creatinine levels tended to diminish on curcumin therapy. These findings suggest that curcumin might have the potential to slow the disease process in patients with MGUS and SMM.

Curcumin & Cigarette smoke

cigarette smoke (CS) can cause all sorts of health problems, including cancers of the larynx, oral cavity and pharynx, esophagus, pancreas, kidney, bladder and lung. [ ] CS is a complex chemical mixture containing thousands of different compounds, of which 100 are known carcinogens, co-carcinogens, mutagens and/or tumor promoters. Known carcinogens, meaning there probably are MORE than 100.

Well, it turns out that curcumin seems to counteract the damaging effects of Cigarette Smoke, and the study ends with a suggestion to conduct clinical trials “of curcumin as a chemopreventive agent in former and current cigarette smokers.”

Here are 2 articles published on it.

http://carcin.oxfordjournals.org/content/24/7/1269.full.pdf  Can just read last sentence.

http://mct.aacrjournals.org/content/6/3/1022.abstract

 

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